CD274 PD-L1

IHC(C, P)

Programmed cell death ligand 1 (PD-L1) also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1) is a type 1 transmembrane protein involved in the regulation of cellular and humoral immune responses. The interaction of PD-L1 with its receptor PD-1 provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy, tissue allograft, autoimmune disease and malignant transformation. The binding of PD-L1 to PD-1 induces apoptosis or exhaustion in activated T cells, and blockade of this interaction has been shown to enhance the antitumor activity of T cells. PD-L1 is frequently over expressed in placenta, and many human tumours such as melanoma, diffuse large B-cell lymphoma, and carcinomas of the lung, bladder, breast, kidney and colon. Human CD274, PD-L1.

*These antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.
** The preservative sodium azide is known to be poisonous and potentially hazardous to health. It should be handled only by trained staff. Despite of the product's low azide concentration it must be handled with care. Dispose according to regional rules!

KLH-conjugated linear peptide from human PD-L1

Placenta, lung carcinoma (NSCLC)

Unmasking with Unmasking fluid E (Art. No. DE006) pH 9.0 or Unmasking fluid T (DE005) pH 8.0

Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide.**

Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide.**

Rabbits were immunized with KLH-conjugated linear peptide from human PD-L1

Human

Human CD274, PD-L1.

Q9NZQ7 (PD1L1_HUMAN)

(liquid conc.) 1:50-1:100