MPI_5a
| Code | Size | Price |
|---|
| SYN-3040-M001 | 1 mg | £104.00 |
Quantity:
| SYN-3040-M005 | 5 mg | £233.00 |
Quantity:
| SYN-3040-M010 | 10 mg | £350.00 |
Quantity:
| SYN-3040-M050 | 50 mg | £1,170.00 |
Quantity:
| SYN-3040-M100 | 100 mg | £1,873.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
MPI5a; N-Hydroxy-2-(1-methyl-1H-pyrrole-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide
Appearance:
Solid.
CAS:
1259296-46-2
EClass:
32160000
Form (Short):
liquid
Hazards:
H303, H317, H333
InChi:
InChI=1S/C16H17N3O3/c1-18-7-2-3-14(18)16(21)19-8-6-11-9-12(15(20)17-22)4-5-13(11)10-19/h2-5,7,9,22H,6,8,10H2,1H3,(H,17,20)
InChiKey:
NNQAQGDSGCGFER-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1259296-46-2. Formula: C16H17N3O3. MW: 299.3. MPI_5a is a potent selective inhibitor of HDAC6. HDAC6 is a predominantly cytoplasmic enzyme that targets alpha-tubulin, cortactin and heat shock protein 90, and other substrates. MPI-5a has an IC50 of 36nM in tumour cell models and inhibits the acetylation of tubulin in cells with an IC50 value of 210nM.
Molecular Formula:
C16H17N3O3
Molecular Weight:
299.3
Package Type:
Plastic Vial
Product Description:
MPI_5a is a potent selective inhibitor of HDAC6. HDAC6 is a predominantly cytoplasmic enzyme that targets alpha-tubulin, cortactin and heat shock protein 90, and other substrates. MPI-5a has an IC50 of 36nM in tumour cell models and inhibits the acetylation of tubulin in cells with an IC50 value of 210nM.
Purity:
>95%
Signal word:
Warning
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
HDAC6: physiological function and its selective inhibitors for cancer treatment: P.H. Yang, et al.; Drug Discov. Ther. 7, 233 (2013) | Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform: C. Blackburn, et al.; J. Med. Chem. 56, 7201 (2013)
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