I-BET762
| Code | Size | Price |
|---|
| SYN-3033-M100 | 100 mg | Enquire |
Quantity:
| SYN-3033-M001 | 1 mg | £104.00 |
Quantity:
| SYN-3033-M005 | 5 mg | £151.00 |
Quantity:
| SYN-3033-M010 | 10 mg | £197.00 |
Quantity:
| SYN-3033-M050 | 50 mg | £537.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
GSK-525762A
Appearance:
Solid.
CAS:
1260907-17-2
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C22H22ClN5O2/c1-4-24-20(29)12-18-22-27-26-13(2)28(22)19-10-9-16(30-3)11-17(19)21(25-18)14-5-7-15(23)8-6-14/h5-11,18H,4,12H2,1-3H3,(H,24,29)/t18-/m0/s1
InChiKey:
AAAQFGUYHFJNHI-SFHVURJKSA-N
Long Description:
Chemical. CAS: 1260907-17-2. Formula: C22H22ClN5O2. MW: 423.9. I-BET762 (GSK525762A) is an inhibitor for BET (bromodomain and extra terminal domain) proteins, BRD2, BRD3 and BRD4. It binds to the tandem bromodomains of BET with a Kd of 50.5-61.3nM, displaces a tetra-acetylated H4 peptide prebound to tandem bromodomains of BET with IC50 of 32.5-42.5nM in FRET analysis. I-BET762 disrupts the formation of the chromatin complexes essential for expression of inflammatory genes.
Molecular Formula:
C22H22ClN5O2
Molecular Weight:
423.9
Package Type:
Plastic Vial
Product Description:
I-BET762 (GSK525762A) is an inhibitor for BET (bromodomain and extra terminal domain) proteins, BRD2, BRD3 and BRD4. It binds to the tandem bromodomains of BET with a Kd of 50.5-61.3nM, displaces a tetra-acetylated H4 peptide prebound to tandem bromodomains of BET with IC50 of 32.5-42.5nM in FRET analysis. I-BET762 disrupts the formation of the chromatin complexes essential for expression of inflammatory genes.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Suppression of inflammation by a synthetic histone mimic: E. Nicodeme, et al.; Nature 468, 1119 (2010) | Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors: H.S. Bandukwala, et al.; PNAS 109, 14532 (2012)
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