AZ9482
| Code | Size | Price |
|---|
| SYN-3046-M100 | 100 mg | Enquire |
Quantity:
| SYN-3046-M001 | 1 mg | £115.00 |
Quantity:
| SYN-3046-M005 | 5 mg | £233.00 |
Quantity:
| SYN-3046-M010 | 10 mg | £350.00 |
Quantity:
| SYN-3046-M050 | 50 mg | £1,053.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
2-(4-(3-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)nicotinonitrile
Appearance:
Solid.
CAS:
1825345-33-2
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C26H22N6O2/c27-17-20-7-4-10-28-24(20)31-11-13-32(14-12-31)26(34)19-6-3-5-18(15-19)16-23-21-8-1-2-9-22(21)25(33)30-29-23/h1-10,15H,11-14,16H2,(H,30,33)
InChiKey:
ZDDPBFWHZOJFHF-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1825345-33-2. Formula: C26H22N6O2. MW: 450.5. AZ9482 is a potent and selective PARP inhibitor featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent centrosome declustering activity in HeLa cells (EC50 < 18nM). AZ9482 also showed a 3nM GI50 in the DLBCL cell line OCI-LY-19 in a 3-day AlamarBlue assay. Consistent with published siRNA knockdown experiments, AZ9482 was a 9nM enzyme inhibitor of tankyrase 1 (TNKS1).
Molecular Formula:
C26H22N6O2
Molecular Weight:
450.5
Package Type:
Plastic Vial
Product Description:
AZ9482 is a potent and selective PARP inhibitor featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent centrosome declustering activity in HeLa cells (EC50 < 18nM). AZ9482 also showed a 3nM GI50 in the DLBCL cell line OCI-LY-19 in a 3-day AlamarBlue assay. Consistent with published siRNA knockdown experiments, AZ9482 was a 9nM enzyme inhibitor of tankyrase 1 (TNKS1).
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering: J.W. Johannes, et al.; Bioorg. Med. Chem. Lett. 25, 5743 (2015)
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