BIX02565
| Code | Size | Price |
|---|
| SYN-1228-M100 | 100 mg | Enquire |
Quantity:
| SYN-1228-M001 | 1 mg | £115.00 |
Quantity:
| SYN-1228-M005 | 5 mg | £233.00 |
Quantity:
| SYN-1228-M010 | 10 mg | £338.00 |
Quantity:
| SYN-1228-M050 | 50 mg | £1,053.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
BIX-02565
Appearance:
Solid.
CAS:
1311367-27-7
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C26H30N6O2/c1-17-11-12-27-25(34)23-15-18-9-10-19(16-22(18)32(17)23)24(33)29-26-28-20-7-4-5-8-21(20)31(26)14-6-13-30(2)3/h4-5,7-10,15-17H,6,11-14H2,1-3H3,(H,27,34)(H,28,29,33)/t17-/m1/s1
InChiKey:
ZHMXXVNQAFCXKK-QGZVFWFLSA-N
Long Description:
Chemical. CAS: 1311367-27-7. Formula: C26H30N6O2. MW: 458.6. BIX 02565 is a novel ribosomal S6 kinase 2 (RSK2) inhibitor with an IC50 of 1.1nM. BIX 02565 also has inhibitory effects on LRRK2, RET, CLK2, FLT3 and PDGFR. BIX 02565 can be used in vitro and in vivo to explore the role of RSK as a target for the treatment heart failure.
Molecular Formula:
C26H30N6O2
Molecular Weight:
458.6
Package Type:
Plastic Vial
Product Description:
BIX 02565 is a novel ribosomal S6 kinase 2 (RSK2) inhibitor with an IC50 of 1.1nM. BIX 02565 also has inhibitory effects on LRRK2, RET, CLK2, FLT3 and PDGFR. BIX 02565 can be used in vitro and in vivo to explore the role of RSK as a target for the treatment heart failure.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Indole RSK inhibitors. Part 2: optimization of cell potency and kinase selectivity: T.M. Kirrane, et al.; Bioorg. Med. Chem. Lett. 22, 738 (2012) | Mitigation of off-target adrenergic binding and effects on cardiovascular function in the discovery of novel ribosomal S6 kinase 2 inhibitors: R.M. Fryer, et al.; J. Pharmacol. Exp. Ther. 340, 492 (2012) | A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870: A.J. Edgar, et al.; Biosci. Rep. 34, e00091 (2014)
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