CFI-400437
| Code | Size | Price |
|---|
| SYN-1207-M100 | 100 mg | Enquire |
Quantity:
| SYN-1207-M050 | 50 mg | Enquire |
Quantity:
| SYN-1207-M001 | 1 mg | £233.00 |
Quantity:
| SYN-1207-M005 | 5 mg | £467.00 |
Quantity:
| SYN-1207-M010 | 10 mg | £771.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
(E)-5-Methoxy-3-((3-((E)-2-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)vinyl)-1H-indazol-6-yl)methylene)indolin-2-one dihydrochloride
Appearance:
Solid.
CAS:
1168722-82-4
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C29H28N6O2.2ClH/c1-34-11-13-35(14-12-34)28-10-5-19(18-30-28)4-8-26-22-7-3-20(16-27(22)33-32-26)15-24-23-17-21(37-2)6-9-25(23)31-29(24)36;;/h3-10,15-18H,11-14H2,1-2H3,(H,31,36)(H,32,33);2*1H/b8-4+,24-15+;;
InChiKey:
XQZOWXHJNLSRCM-AEZZRCKESA-N
Long Description:
Chemical. CAS: 1168722-82-4. Formula: C29H28N6O2 . 2HCl. MW: 492.6 . 72.9. CFI-400437 is a potent PLK4 inhibitor (IC50=0.6nM) and selective against other members of the PLK family (>10µM). Against a broad panel of kinases, only a small subset is significantly inhibited. CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB-231 cell growth and very effective in a mouse xenograft model of tumor growth.
Molecular Formula:
C29H28N6O2 . 2HCl
Molecular Weight:
492.6 . 72.9
Package Type:
Plastic Vial
Product Description:
CFI-400437 is a potent PLK4 inhibitor (IC50=0.6nM) and selective against other members of the PLK family (>10µM). Against a broad panel of kinases, only a small subset is significantly inhibited. CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB-231 cell growth and very effective in a mouse xenograft model of tumor growth.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at +4°C.
References
The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents: R. Laufer, et al.; J. Med. Chem. 56, 6069 (2013)
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