GSK-J1
| Code | Size | Price |
|---|
| SYN-3030-M100 | 100 mg | Enquire |
Quantity:
| SYN-3030-M001 | 1 mg | £80.00 |
Quantity:
| SYN-3030-M005 | 5 mg | £115.00 |
Quantity:
| SYN-3030-M010 | 10 mg | £186.00 |
Quantity:
| SYN-3030-M050 | 50 mg | £654.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine
Appearance:
Solid.
CAS:
1373422-53-7
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C22H23N5O2/c28-21(29)8-12-24-19-15-20(26-22(25-19)18-7-3-4-11-23-18)27-13-9-16-5-1-2-6-17(16)10-14-27/h1-7,11,15H,8-10,12-14H2,(H,28,29)(H,24,25,26)
InChiKey:
AVZCPICCWKMZDT-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1373422-53-7. Formula: C22H23N5O2. MW: 389.5. GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A), with IC50 values of 28nM and 53nM, respectively. GSK-J1 also has less potent inhibitory activity against KDM5B, KDM5C and KDM5A, with IC50 values of 170, 550 and 6,800nM, respectively. It shows no activity against other histone demethylases (IC50 >20µM), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30µM.
Molecular Formula:
C22H23N5O2
Molecular Weight:
389.5
Package Type:
Plastic Vial
Product Description:
GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A), with IC50 values of 28nM and 53nM, respectively. GSK-J1 also has less potent inhibitory activity against KDM5B, KDM5C and KDM5A, with IC50 values of 170, 550 and 6,800nM, respectively. It shows no activity against other histone demethylases (IC50 >20µM), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30µM.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response: J. Kruidenier, et al.; Nature 488, 404 (2012) | Inhibition of demethylases by GSK-J1/J4: B. Heinemann, et al.; Nature 514, E1 (2014)
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