AZD-1208
| Code | Size | Price |
|---|
| SYN-1214-M100 | 100 mg | Enquire |
Quantity:
| SYN-1214-M001 | 1 mg | £80.00 |
Quantity:
| SYN-1214-M005 | 5 mg | £104.00 |
Quantity:
| SYN-1214-M010 | 10 mg | £127.00 |
Quantity:
| SYN-1214-M050 | 50 mg | £420.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
AZD-1208
Appearance:
Solid.
CAS:
1204144-28-4
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C21H21N3O2S/c22-16-9-5-11-24(13-16)19-15(12-18-20(25)23-21(26)27-18)8-4-10-17(19)14-6-2-1-3-7-14/h1-4,6-8,10,12,16H,5,9,11,13,22H2,(H,23,25,26)/b18-12-/t16-/m1/s1
InChiKey:
MCUJKPPARUPFJM-UWCCDQBKSA-N
Long Description:
Chemical. CAS: 1204144-28-4. Formula: C21H21N3O2S. MW: 379.5. Potent, highly selective and orally available Pim kinase inhibitor that effectively inhibits all three isoforms Pim-1, Pim-2 and Pim-3 at <5nM or <150 nM in enzyme and cell assays, respectively. Potently inhibits colony growth and Pim signalling substrates in primary AML cells from bone marrow that are Flt3 wild-type or Flt3 internal tandem duplication mutants. Upregulation of Pim kinases is observed in several types of leukemias and lymphomas. Pim-1, -2 and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways.
Molecular Formula:
C21H21N3O2S
Molecular Weight:
379.5
Package Type:
Plastic Vial
Product Description:
Potent, highly selective and orally available Pim kinase inhibitor that effectively inhibits all three isoforms Pim-1, Pim-2 and Pim-3 at < 5nM or < 150 nM in enzyme and cell assays, respectively. Potently inhibits colony growth and Pim signalling substrates in primary AML cells from bone marrow that are Flt3 wild-type or Flt3 internal tandem duplication mutants. Upregulation of Pim kinases is observed in several types of leukemias and lymphomas. Pim-1, -2 and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases: L.A. Dakin, et al.; Bioorg. Med. Chem. Lett. 22, 4599 (2012) | AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia: E.K. Keeton, et al.; Blood 123, 905 (2014) | The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling: B. Cen, et al.; Mol. Cell Biol. 34, 2517 (2014)
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