GE2270 D2
Product Code: AG-CN2-0304
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0304-M001 | 1 mg | £90.00 |
Quantity:
| AG-CN2-0304-M005 | 5 mg | £300.00 |
Quantity:
| AG-CN2-0304-M025 | 25 mg | £880.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Antibiotic GE2270D2
Appearance:
White to off-white powder.
CAS:
138948-60-4
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.Protect from light.Protect from light when in solution.
InChi:
InChI=1S/C55H53N15O10S6/c1-23(2)38-54-69-41(35(17-71)86-54)46(77)58-16-37(73)66-42(43(74)25-9-6-5-7-10-25)53-65-33(22-84-53)51-62-30(19-82-51)40-26(49-63-31(20-81-49)45(76)60-28(15-36(72)57-4)52-68-39(24(3)85-52)47(78)67-38)12-13-27(59-40)50-64-32(21-83-50)48-61-29(18-80-48)55(79)70-14-8-11-34(70)44(56)75/h5-7,9-10,12-13,19-23,28-29,34,38,42-43,71,74H,8,11,14-18H2,1-4H3,(H2,56,75)(H,57,72)(H,58,77)(H,60,76)(H,66,73)(H,67,78)
InChiKey:
OKGFXSMHEYOSSF-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 138948-60-4. Formula: C55H53N15O10S6. MW: 1276.5. Isolated from Planobispora rosea. Thiopeptide antibiotic. Congener of GE2270A. Used as a starting scaffold bearing a free hydroxy group, for the production of new interesting semi-synthetic antibiotics. Antibacterial agent by inhibiting bacterial protein synthesis. Active against numerous Gram-positive pathogens. Inhibitor of elongation factor Tu (EF-Tu). Inhibits protein synthesis by blocking the GDP to GTP conformational change and by directly competing with aminoacyl-tRNA for the same binding site on EF-Tu.
Molecular Formula:
C55H53N15O10S6
Molecular Weight:
1276.5
Other data:
Purity Note:The purity is referred exclusively to the main congener(s), the sample also contains minor related congeners. See: Components of the Ge2270 complex produced by Planobispora rosea ATCC 53773: E. Selva, et al.; J. Antibiot. 48, 1039 (1995)
Package Type:
Vial
Product Description:
Thiopeptide antibiotic. Congener of GE2270A (AG-CN2-0303 https://adipogen.com/ag-cn2-0303-ge2270a.html ). Used as a starting scaffold bearing a free hydroxy group, for the production of new interesting semi-synthetic antibiotics. Antibacterial agent by inhibiting bacterial protein synthesis. Active against numerous Gram-positive pathogens. Inhibitor of elongation factor Tu (EF-Tu). Inhibits protein synthesis by blocking the GDP to GTP conformational change and by directly competing with aminoacyl-tRNA for the same binding site on EF-Tu.
Purity:
>80% (HPLC)
SMILES:
OCC1=C(C(NCC(NC(C(C2=CC=CC=C2)O)C3=NC(C4=NC(C5=C(C=CC(C6=NC(C7=NC(C(N8C(CCC8)C(N)=O)=O)CO7)=CS6)=N5)C9=NC(C(NC(CC(NC)=O)C%10=NC(C(NC%11C(C)C)=O)=C(C)S%10)=O)=CS9)=CS4)=CS3)=O)=O)N=C%11S1
Solubility Chemicals:
Soluble in DMSO or other organic solvents.
Source / Host:
Isolated from Planobispora rosea.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Antibiotic GE2270 A: a novel inhibitor of bacterial protein synthesis. I. Isolation and characterization: E. Selva, et al.; J. Antibiot. 44, 693 (1991) | Components of the GE2270 complex produced by Planobispora rosea ATCC 53773: E. Selva, et al.; J. Antibiot. 48, 1039 (1995) | Contribution of mass spectrometry to the structural confirmation of components of the antibiotic GE2270 complex: L. Colombo, et al.; Rap. Commun. Mass. Spec. 9, 717 (1995) | Antimicrobial activities of chemically modified thiazolyl peptide antibiotic MDL 62,879 (GE2270A): S. Lociuro, et al.; J. Antibiot. 50, 344 (1997) | Capturing linear intermediates and C-terminal variants during maturation of the thiopeptide GE2270: A. Tocchetti, et al.; Chem. Biol. 20, 1067 (2013) | Elfamycins: inhibitors of elongation factor-Tu: S.M. Prezioso, et al.; Mol. Microbiol. 106, 22 (2017) (Review)
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