Neuromedin U-25 (human)
| Code | Size | Price |
|---|
| AG-CP3-0031-M001 | 1 mg | £140.00 |
Quantity:
| AG-CP3-0031-M005 | 5 mg | £530.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Shipping:
AMBIENT
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
NMU-25; FRVDEEFQSPFASQSRGYFLFRPRN-NH2 . TFA
Appearance:
Lyophilized powder.
CAS:
312306-89-1
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.
InChi:
InChI=1S/C141H203N41O38.C2HF3O2/c1-74(2)61-94(125(208)173-98(65-80-33-17-9-18-34-80)128(211)169-92(40-24-58-158-141(153)154)136(219)181-59-25-41-104(181)133(216)168-86(38-22-56-156-139(149)150)118(201)170-93(114(146)197)68-108(145)189)171-129(212)99(66-81-35-19-10-20-36-81)174-126(209)95(67-82-43-45-83(186)46-44-82)161-109(190)70-159-117(200)85(37-21-55-155-138(147)148)163-132(215)102(72-184)178-121(204)88(47-51-106(143)187)167-131(214)101(71-183)177-115(198)76(5)160-124(207)96(63-78-29-13-7-14-30-78)175-134(217)105-42-26-60-182(105)137(220)103(73-185)179-122(205)89(48-52-107(144)188)165-127(210)97(64-79-31-15-8-16-32-79)172-120(203)91(50-54-111(193)194)164-119(202)90(49-53-110(191)192)166-130(213)100(69-112(195)196)176-135(218)113(75(3)4)180-123(206)87(39-23-57-157-140(151)152)162-116(199)84(142)62-77-27-11-6-12-28-77;3-2(4,5)1(6)7/h6-20,27-36,43-46,74-76,84-105,113,183-186H,21-26,37-42,47-73,142H2,1-5H3,(H2,143,187)(H2,144,188)(H2,145,189)(H2,146,197)(H,159,200)(H,160,207)(H,161,190)(H,162,199)(H,163,215)(H,164,202)(H,165,210)(H,166,213)(H,167,214)(H,168,216)(H,169,211)(H,170,201)(H,171,212)(H,172,203)(H,173,208)(H,174,209)(H,175,217)(H,176,218)(H,177,198)(H,178,204)(H,179,205)(H,180,206)(H,191,192)(H,193,194)(H,195,196)(H4,147,148,155)(H4,149,150,156)(H4,151,152,157)(H4,153,154,158);(H,6,7)/t76-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,113-;/m0./s1
InChiKey:
SJLXOEXLOIEAIN-PJDLJQKUSA-N
Long Description:
Chemical. CAS: 312306-89-1. Formula: C141H203N41O38 . C2HF3O2. MW: 3080.4 . 114.0. Synthetic. Active human form of NMU. Binds to two high affinity G-protein coupled receptors, NMUR1 and NMUR2, with NMUR1 predominantly expressed in the peripheral tissues and NMUR2 mainly expressed in the CNS. The activation of NMURs leads to intracellular signal transduction via calcium mobilization, phosphoinositide (or PI) signaling and the inhibition of cAMP production and therefore has diverse functions including contraction of smooth muscle, vasoconstriction, nociception, appetite and bone remodeling. Implicated in a number of physiological processes including the regulation of feeding, energy homeostasis and glycemic control and therefore used to target obesity and diabetes. Activator of innate lymphoid cells 2 (ILC2) during inflammation, as shown in studies in mice.
MDL:
MFCD03457694
Molecular Formula:
C141H203N41O38 . C2HF3O2
Molecular Weight:
3080.4 . 114.0
Package Type:
Vial
Product Description:
Active human form of NMU. Binds to two high affinity G-protein coupled receptors, NMUR1 and NMUR2, with NMUR1 predominantly expressed in the peripheral tissues and NMUR2 mainly expressed in the CNS. The activation of NMURs leads to intracellular signal transduction via calcium mobilization, phosphoinositide (or PI) signaling and the inhibition of cAMP production and therefore has diverse functions including contraction of smooth muscle, vasoconstriction, nociception, appetite and bone remodeling. Implicated in a number of physiological processes including the regulation of feeding, energy homeostasis and glycemic control and therefore used to target obesity and diabetes. Activator of innate lymphoid cells 2 (ILC2) during inflammation, as shown in studies in mice [6-8].
Purity:
>98% (HPLC)
Sequence:
H-Phe-Arg-Val-Asp-Glu-Glu-Phe-Gln-Ser-Pro-Phe-Ala-Ser-Gln-Ser-Arg-Gly-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-amide
SMILES:
C[C@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CC2=CC=CC=C2)=O)CCCNC(N)=N)=O)C(C)C)=O)CC(O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CC3=CC=CC=C3)=O)CCC(N)=O)=O)CO)=O)=O)CC4=CC=CC=C4)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N5CCC[C@H]5C(N[C@H](C(N[C@H](C(N)=O)CC(N)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CC6=CC=CC=C6)=O)CC(C)C)=O)CC7=CC=CC=C7)=O)CC8=CC=C(O)C=C8)=O)=O)CCCNC(N)=N)=O)CO)=O)CCC(N)=O)=O)CO)=O.FC(F)(C(O)=O)F
Solubility Chemicals:
Soluble in water.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system: J.D. Mitchell, et al.; Cardiovasc. Res. 81, 353 (2009) | Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S: J.D. Mitchell, et al.; Br. J. Pharmacol. 158, 87 (2009) (Review) | Peptides and their potential role in the treatment of diabetes and obesity: H.C. Greenwood, et al.; Rev. Diabet. Stud. 8, 355 (2011) (Review) | Suppression of insulin production and secretion by a decretin hormone: R. W. Alfa, et al.; Cell Metab. 21, 323 (2015) | Neuromedin U: a multifunctional neuropeptide with pleiotropic roles: V.G. Martinez & L. O'Driscoll; Clin. Chem. 61, 471 (2015) (Review) | The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation: C.S.N. Klose, et al.; Nature 549, 282 (2017) | The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation: A. Wallrapp, et al.; Nature 549, 351 (2017) | Neuronal regulation of type 2 innate lymphoid cells via neuromedin U: V. Cardoso, et al.; Nature 549, 277 (2017)