MOTS-c (K14Q Mutant) (human)

H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Gln-Leu-Arg-OH . TFA; Mitochondrial Open Reading Frame of the 12S rRNA-c K14Q Mutant; MOTS3 K14Q Mutant

Solid lyophilized powder.

32160000

liquid

Keep cool and dry.

InChI=1S/C100H148N28O23S2.C2HF3O2/c1-7-55(4)82(95(148)125-74(48-56-17-9-8-10-18-56)91(144)126-76(50-58-27-31-61(130)32-28-58)96(149)128-44-16-24-77(128)94(147)121-66(22-14-42-111-99(106)107)85(138)117-68(34-37-79(103)132)89(142)123-72(47-54(2)3)90(143)122-71(97(150)151)23-15-43-112-100(108)109)127-93(146)73(49-57-25-29-60(129)30-26-57)115-80(133)53-114-84(137)70(40-46-153-6)120-88(141)69(35-38-81(134)135)118-87(140)67(33-36-78(102)131)119-92(145)75(51-59-52-113-64-20-12-11-19-62(59)64)124-86(139)65(21-13-41-110-98(104)105)116-83(136)63(101)39-45-152-5;3-2(4,5)1(6)7/h8-12,17-20,25-32,52,54-55,63,65-77,82,113,129-130H,7,13-16,21-24,33-51,53,101H2,1-6H3,(H2,102,131)(H2,103,132)(H,114,137)(H,115,133)(H,116,136)(H,117,138)(H,118,140)(H,119,145)(H,120,141)(H,121,147)(H,122,143)(H,123,142)(H,124,139)(H,125,148)(H,126,144)(H,127,146)(H,134,135)(H,150,151)(H4,104,105,110)(H4,106,107,111)(H4,108,109,112);(H,6,7)/t55-,63-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,82-;/m0./s1

DXUYVBXOAGWAKV-JBICZICZSA-N

Chemical. Formula: C100H148N28O23S2 . C2HF3O2. MW: 2174.6 . 114.0. Synthetic. The mitochondria-derived peptide (MDP) MOTS-c promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase (AMPK). It induces cellular and systemic glucose uptake and improves insulin sensitivity and has been shown to prevent diet-induced obesity (DIO) in mice. This K14Q mutant of MOTS-c has been shown to be associated with exceptional longevity and may be interesting for aging research.

C100H148N28O23S2 . C2HF3O2

2174.6 . 114.0

Vial

The mitochondria-derived peptide (MDP) MOTS-c promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase (AMPK). It induces cellular and systemic glucose uptake and improves insulin sensitivity and has been shown to prevent diet-induced obesity (DIO) in mice. This K14Q mutant of MOTS-c has been shown to be associated with exceptional longevity and may be interesting for aging research.

>95% (HPLC)

H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Gln-Leu-Arg-OH

[H]N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)CC3=CC=CC=C3)=O)[C@@H](C)CC)=O)CC4=CC=C(O)C=C4)=O)=O)CCSC)=O)=O)=O)CC5=CNC6=C5C=CC=C6)=O)=O)CCSC.O=C(O)C(F)(F)F

Soluble in water.

Synthetic.

Non-hazardous

Biochemical Reagents

12352200

Stable for at least 1 year after receipt when stored at -20°C.