Cordycepin
| Code | Size | Price |
|---|
| CDX-C0339-M010 | 10 mg | £59.00 |
Quantity:
| CDX-C0339-M025 | 25 mg | £126.00 |
Quantity:
| CDX-C0339-M100 | 100 mg | £340.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
3'-Deoxyadenosine; NSC 63984; NSC 401022; 9-Cordyceposidoadenine; BRN 0035194
Appearance:
White to off-white powder.
CAS:
73-03-0
Class:
6.1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS06
Handling Advice:
Keep cool and dry.Protect from light and moisture.
Hazards:
H301
InChi:
InChI=1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,10+/m0/s1
InChiKey:
OFEZSBMBBKLLBJ-BAJZRUMYSA-N
Long Description:
Chemical. CAS: 73-03-0. Formula: C10H13N5O3. MW: 251.24. Synthetic. Cordycepin is a nucleoside (adenosine analog) antibiotic that acts as a polyadenylation inhibitor when converted to 3?-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA and RNA synthesis. Cordycepin has a broad spectrum of biological activities, including anticancer, anti-proliferative, pro-apoptotic, anti-inflammatory and antifungal effects. It was shown to modulate autophagy and NLRP3 inflammasome. Cordycepin has been shown to reduce poly(A) tail length in mRNA, to activate AMPK kinase, leading to a reduction in mTOR signalling, downregulate ERK/Akt/PI3K/GSK-3beta/beta-catenin signaling pathways. Also useful for the study of messenger RNA transcription.
MDL:
MFCD00037998
Molecular Formula:
C10H13N5O3
Molecular Weight:
251.24
Package Type:
Vial
PG:
III
Precautions:
P301, P310
Product Description:
Cordycepin is a nucleoside (adenosine analog) antibiotic that acts as a polyadenylation inhibitor when converted to 3?-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA and RNA synthesis. Cordycepin has a broad spectrum of biological activities, including anticancer, anti-proliferative, pro-apoptotic, anti-inflammatory and antifungal effects. It was shown to modulate autophagy and NLRP3 inflammasome. Cordycepin has been shown to reduce poly(A) tail length in mRNA, to activate AMPK kinase, leading to a reduction in mTOR signalling, downregulate ERK/Akt/PI3K/GSK-3beta/beta-catenin signaling pathways. Also useful for the study of messenger RNA transcription.
Purity:
>98% (HPLC)
Signal word:
Danger
SMILES:
OC[C@@H]1C[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O1
Solubility Chemicals:
Soluble in water, ethanol or DMSO.
Source / Host:
Synthetic.
Transportation:
Excepted Quantity
UN Nummer:
UN 2811
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) G.G. Lovinger, et al.; Virology 55, 524 (1973) | (2) R.I. Gumport, et al.; Biochemistry 15, 2804 (1976) | (3) A.M. Sugar & R.P. McCaffrey; Antimicrob. Agents Chemother. 42, 1424 (1998) | (4) E.N. Kodama, et al.; Biochem. Pharmacol. 59, 273 (2000) | (5) L.S. Chen, et al.; Br. J. Haematol. 140, 682 (2008) | (6) Y.Y. Wong, et al.; J. Biol. Chem. 285, 2610 (2010) | (7) H.J. Lee, et al.; Invest. New Drugs 30, 1917 (2012) | (8) B.S. Ko, et al.; PLoS One 8, e76320 (2013) | (9) H.S. Tuli, et al.; Life Sci. 93, 863 (2013) (Review) | (10) C. Wu, et al.; J. Cell Mol. Med. 18, 293 (2014) | (11) K. Nakamura, et al.; J. Pharmacol. Sci. 127, 53 (2015) (Review) | (12) Y. Li, et al.; Oncol. Lett. 9, 2541 (2015) | (13) J. Yang, et al.; Biomed. Pharmacother. 95, 1777 (2017) | (14) Y. Wang, et al.; Exp. Ther. Med. 14, 3067 (2017)
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