Fisetin
| Code | Size | Price |
|---|
| CDX-F0336-M100 | 100 mg | £41.00 |
Quantity:
| CDX-F0336-M500 | 500 mg | £84.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
3,3',4',7-Tetrahydroxyflavone; 5-Deoxyquercetin; Natural Brown 1; CI-75620; NSC 407010; NSC 656275; BRN 0292829; Cotinin
Appearance:
Yellow powder.
CAS:
528-48-3
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H
InChiKey:
XHEFDIBZLJXQHF-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 528-48-3. Formula: C15H10O6. MW: 286.24. Synthetic. One of the major polyphenolic flavonoids found in various fruits and vegetables such as apples, grapes, persimmons, strawberries, cucumbers and onions. Exerts numerous beneficial biological activities, including antibacterial, antifungal, antioxidant, anti-inflammatory, antiangiogenic, antiproliferative, proapoptotic, cell cycle arrest, autophagy inducing, hypolipidemic, neuroprotective and antitumor effects. Modulates multiple signaling pathways such as blocking of the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) and p38, mitogen-activated protein kinases (MAPK)-dependent nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) signaling, Wnt and adrogen receptor signaling, which playing a central role in various cellular processes contributing to the malignancy. Binds to beta-tubulin and disrupts microtubule dynamics. Activator of sirtuin 1 and PPARs, inhibitor of DNA topoisomerase II (topo II), inhibitor of CDK6and GSK-3beta. Recently used as fluorescent molecular probe in sodium dodecyl sulfate (SDS) induced Sol-Gel transition.
MDL:
MFCD04220857
Molecular Formula:
C15H10O6
Molecular Weight:
286.24
Package Type:
Vial
Product Description:
One of the major polyphenolic flavonoids found in various fruits and vegetables such as apples, grapes, persimmons, strawberries, cucumbers and onions. Exerts numerous beneficial biological activities, including antibacterial, antifungal, antioxidant, anti-inflammatory, antiangiogenic, antiproliferative, proapoptotic, cell cycle arrest, autophagy inducing, hypolipidemic, neuroprotective and antitumor effects. Modulates multiple signaling pathways such as blocking of the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) and p38, mitogen-activated protein kinases (MAPK)-dependent nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) signaling, Wnt and adrogen receptor signaling, which playing a central role in various cellular processes contributing to the malignancy. Binds to beta-tubulin and disrupts microtubule dynamics. Activator of sirtuin 1 and PPARs, inhibitor of DNA topoisomerase II (topo II), inhibitor of CDK6and GSK-3beta. Recently used as fluorescent molecular probe in sodium dodecyl sulfate (SDS) induced Sol-Gel transition.
Purity:
>98% (HPLC)
SMILES:
OC1=CC=C2C(OC(C3=CC(O)=C(O)C=C3)=C(O)C2=O)=C1
Solubility Chemicals:
Soluble in DMSO (10mg/ml), DMF (10mg/ml) or ethanol (2mg/ml).
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) M. Gabor & E. Eperjessy; Nature 212, 1273 (1966) | (2) A.J. Olaharski, et al.; Mutat. Res. 582, 79 (2005) | (3) B. Sung, et al.; Mol. Pharmacol. 71, 1703 (2007) | (4) N. Khan, et al.; Carcinogenesis 29, 1049 (2008) | (5) B.G. Szczepankiewicz & P.Y. Ng; Curr. Top. Med. Chem. 8, 1533 (2008) (Review) | (6) Y. Suh, et al.; Carcinogenesis 30, 300 (2009) | (7) Y. Suh, et al.; Carcinogenesis 31, 1424 (2010) | (8) R. Singh, et al.; J. Med. Chem. 55, 3614 (2012) | (9) V.M. Adhami, et al.; Biochem. Pharmacol. 84, 1277 (2012) (Review) | (10) D.N. Syed, et al.; Anticancer Agents Med. Chem. 13, 995 (2013) (Review) | (11) N. Khan, et al.; Antioxid. Redox Signal. 19, 151 (2013) (Review) | (12) C.H. Jung, et al.; J. Nutr. Biochem. 24, 1547 (2013) | (13) G.S. Prasath, et al.; Eur. J. Pharmacol. 740, 248 (2014) | (14) T. Jin, et al.; J. Agric. Food Chem. 62, 10468 (2014) | (15) E. Mukhtar, et al.; Cancer Lett. 367, 173 (2015) | (16) M.P. Reis, et al.; J. Appl. Microbiol. 121, 373 (2016) | (17) S.F. Nabavi, et al.; Curr. Top. Med. Chem. 16, 1910 (2016) (Review) | (18) T. Rengarajan & N.S. Yaacob; Eur. J. Pharmacol. 789, 8 (2016) (Review) | (19) M. Youns, et al.; PLoS One 12, e0169335 (2017) | (20) J. Mishra, et al.; J. Phys. Chem. B 122, 181 (2018) | (21) K D. Kashyap, et al.; Life Sci. 194, 75 (2018) (Review) | (22) K. Shanmugam, et al.; Oxid. Med. Cell Longev. 2018, 9173436 (2018)
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