S-Phenylmercapturic acid
| Code | Size | Price |
|---|
| CDX-P0091-M100 | 100 mg | £126.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
N-Acetyl-S-phenyl-L-cysteine; (R)-2-Acetamido-3-(phenylthio)propanoic acid; NSC 17197; S-PMA
Appearance:
White crystalline powder.
CAS:
4775-80-8
EClass:
32160000
Form (Short):
solid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C11H13NO3S/c1-8(13)12-10(11(14)15)7-16-9-5-3-2-4-6-9/h2-6,10H,7H2,1H3,(H,12,13)(H,14,15)
InChiKey:
CICOZWHZVMOPJS-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 4775-80-8. Formula: C11H13NO3S. MW: 239.29. Synthetic. S-Phenylmercapturic acid (S-PMA) is an important metabolite of benzene used as a biomarker for benzene exposure in humans. In industrial workers, urinary concentrations of up to 543 µg/g creatinine have been detected. In a study of benzene exposure through tobacco smoke inhalation in humans, smokers had a urinary concentration of 9.1 µg S-PMA/g creatinine compared with 4.8 µg S-PMA/g creatinine in non-smokers. S-PMA can be sensitively and reliably determined using capillary gas chromatographic/mass spectrometric method. Due to its sensitivity the method is suitable not only for determining concentrations relevant to occupational medicine, but also those which occur in the ecological range. Compound can be used as analytical reference material.
MDL:
MFCD16661257
Molecular Formula:
C11H13NO3S
Molecular Weight:
239.29
Package Type:
Vial
Product Description:
S-Phenylmercapturic acid (S-PMA) is an important metabolite of benzene used as a biomarker for benzene exposure in humans. In industrial workers, urinary concentrations of up to 543 µg/g creatinine have been detected. In a study of benzene exposure through tobacco smoke inhalation in humans, smokers had a urinary concentration of 9.1 µg S-PMA/g creatinine compared with 4.8 µg S-PMA/g creatinine in non-smokers. S-PMA can be sensitively and reliably determined using capillary gas chromatographic/mass spectrometric method. Due to its sensitivity the method is suitable not only for determining concentrations relevant to occupational medicine, but also those which occur in the ecological range. Compound can be used as analytical reference material.
Purity:
>98% (HPLC)
SMILES:
CC(N[C@H](C(O)=O)CSC1=CC=CC=C1)=O
Solubility Chemicals:
Soluble in DMSO, DMF or ethanol.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) P. Stommel, et al.; Carcinogenesis 10, 279 (1989) | (2) N.J. van Sittert, et al.; Br. J. Ind. Med. 50, 460 (1993) | (3) J.P. Aston, et al.; Biomarkers 7, 103 (2002) | (4) P.B. Farmer, et al.; Chem. Biol. Interact. 153-154, 97 (2005) | (5) C.A. Haiman, et al.; PLoS One 11, e0150641 (2016) | (6) M.P.R. Mendes, et al.; J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 1063, 136 (2017)