Paclitaxel

Product Code: CDX-P0188

Product Group: Antibiotics and Other Antimicrobials

Supplier: Chemodex

Code	Size	Price

CDX-P0188-M010

10 mg

£72.00

Quantity:

CDX-P0188-M050

50 mg

£169.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO

Shipping:

AMBIENT

Storage:

+4°C

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Documents

Further Information

Alternate Names/Synonyms:

Taxol; BMS 181339-01; NSC 125973

Appearance:

White to off-white powder.

CAS:

33069-62-4

EClass:

32160000

Form (Short):

liquid

GHS Symbol:

GHS08

Handling Advice:

Protect from light and moisture.

Hazards:

H341-H360-H371-H413

InChi:

InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

InChiKey:

RCINICONZNJXQF-MZXODVADSA-N

Long Description:

Chemical. CAS: 33069-62-4. Formula: C47H51NO14. MW: 853.91. Synthetic. Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposi's sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase. Apoptosis inducer through aberrant activation of cyclin-dependent kinases (CKDs) and the c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK). Immunosuppressor, immunostimulant and TRAIL sensitizer.

MDL:

MFCD00869953

Molecular Formula:

C47H51NO14

Molecular Weight:

853.91

Package Type:

Vial

Precautions:

P201-P260-P280-P308 + P313

Product Description:

Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposi's sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase. Apoptosis inducer through aberrant activation of cyclin-dependent kinases (CKDs) and the c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK). Immunosuppressor, immunostimulant and TRAIL sensitizer.

Purity:

>98%

Signal word:

Danger

SMILES:

O[C@](C(C)(C)C1=C(C)[C@H]2OC([C@@H]([C@H](C3=CC=CC=C3)NC(C4=CC=CC=C4)=O)O)=O)(C2)[C@H]([C@]([C@]([C@@H](O)C5)(C)C([C@@H]1OC(C)=O)=O)([H])[C@]6([C@]5([H])OC6)OC(C)=O)OC(C7=CC=CC=C7)=O

Solubility Chemicals:

Soluble in DMSO (50 mg/ml), methanol (50 mg/ml) or ethanol.

Source / Host:

Synthetic.

Transportation:

Non-hazardous

UNSPSC Category:

Biochemical Reagents

UNSPSC Number:

12352200

Use & Stability:

Stable for at least 2 years after receipt when stored at +4°C.

References

(1) J.E. Liebmann, et al.; Br. J. Cancer 68, 1104 (1993) | (2) R. Foa, et al.; Int. J. Clin. Lab. Res. 24, 6 (1994) (Review) | (3) M. Woods, et al.; Mol. Med. 1, 506 (1995) | (4) A. Jordan, et al.; Med. Res. Rev. 18, 259 (1998) | (5) L.A. Amos & J. L?we; Chem. Biol. 6, R65 (1999) (Review) | (6) M.V. Blagosklonny & T. Fojo; Int. J. Cancer 83, 151 (1999) | (7) T.H. Wang, et al.; J. Biol. Chem. 274, 8208 (1999) | (8) T.H. Wang, et al.; Cancer 88, 2619 (2000) | (9) T.M. Mekhail & M. Markman; Expert Opin. Pharmacother. 3, 755 (2002) | (10) A. Javeed, et al.; Eur. J. Pharm. Sci. 38, 283 (2009) (Review) | (11) D. Finlay, et al.;PLoS One 5, e13375 (2010) | (12) B. Ai, et al.; Am. J. Cancer Res. 6, 1624 (2016) (Review)

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