Triptolide
| Code | Size | Price |
|---|
| CDX-T0237-M001 | 1 mg | £102.00 |
Quantity:
| CDX-T0237-M005 | 5 mg | £353.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
PG 490; NSC163062; TPL
Appearance:
White to off-white powder.
CAS:
38748-32-2
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11?,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
InChiKey:
DFBIRQPKNDILPW-KTGKZQHOSA-N
Long Description:
Chemical. CAS: 38748-32-2. Formula: C20H24O6. MW: 360.4. Synthetic. Potent immunosuppressant with anti-inflammatory and antitumor properties. Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators. Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH). Interferes with a number of transcription factors including p53, NF-kappaB, nuclear factor of activated T cells (NFAT) and heat shock factor protein 1 (HSF-1). Shown to inhibit aromatase activity.
MDL:
MFCD00210565
Molecular Formula:
C20H24O6
Molecular Weight:
360.4
Package Type:
Vial
Product Description:
Potent immunosuppressant with anti-inflammatory and antitumor properties. Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators. Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH). Interferes with a number of transcription factors including p53, NF-kappaB, nuclear factor of activated T cells (NFAT) and heat shock factor protein 1 (HSF-1). Shown to inhibit aromatase activity.
Purity:
>98% (HPLC)
SMILES:
O=C(OC1)C2=C1C(C[C@H](O3)[C@]43[C@@]56[C@@H](O6)[C@H]7[C@@](O7)(C(C)C)[C@H]4O)[C@]5(C)CC2
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) S.M. Kupchan, et al.; JACS 94, 7194 (1972) | (2) Y. Yang, et al.; Immunopharmacology 40, 139 (1998) | (3) H. Liu, et al.; Acta Pharmacol. Sin. 21, 782 (2000) | (4) B.J. Chen; Leuk. Lymphoma 42, 253 (2001) (Review) | (5) S. Yang, et al.; Mol. Cancer Ther. 2, 65 (2003) | (6) S.M. Johnson, et al.; J. Surg. Res. 168, 197 (2011) | (7) J. Pan; Cancer Lett. 292, 149 (2010) (Review) | (8) N. Mujumdar, et al.; Gastroenterol. 139, 598 (2010) | (9) D.V. Titov, et al.; Nat. Chem. Biol. 7, 182 (2011) | (10) J. Zhang, et al.; Arzneimittelforschung 61, 727 (2011) | (11) Y. Lu, et al.; Chem. Biol. 21, 246 (2014)
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