ABCG1 Antibody

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NSJ Bioreagents
Product Code: NSJ-R30967
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-R30967-100ug100 ug£535.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
After reconstitution, the ABCG1 antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.

Images

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Western blot testing of ABCG1 antibody and Lane 1: U87; 2: SMMC-7721; 3: HeLa; 4: COLO320; 5: MCF-7 cell lysate. Predicted molecular weight: 75~90KD
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Western blot testing of ABCG1 antibody and Lane 1: U87; 2: SMMC-7721; 3: HeLa; 4: COLO320; 5: MCF-7 cell lysate. Predicted molecular weight: 75~90KD

Documents

Further Information

Application Details :
Western blot: 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting amounts. Titration of the ABCG1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
ABCG1 (ATP-binding cassette, subfamily G, member 1) also known as ABC8, is a protein that in humans is encoded by the ABCG1 gene. ABCG1 is a regulator of macrophage cholesterol and phospholipid transport. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. The gene is mapped on 21q22.3. This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. ABCG1 is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. Inhibition of ABCG1 protein expression using an antisense strategy resulted in reduced HDL3-dependent efflux of cholesterol and choline-phospholipids. In macrophages, silencing of GPS2 by RNA interference reducedABCG1expression and diminished ABCG1-mediated cholesterol efflux.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
An amino acid sequence from the C-terminus of human ABCG1 (ETCHFQKSEAILRELDVENAK) was used as the immunogen for this ABCG1 antibody (100% homologous in human, mouse and rat).
Limitation:
This ABCG1 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse, Rat
Uniprot #:
P45844