NSJ Bioreagents

ACE Antibody

Product Code:
 
NSJ-R31546
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry- Frozen Section (IHC-F)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
After reconstitution, the ACE antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.
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Western blot testing of ACE antibody and recombinant human protein (0.5ng)
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IHC-P: ACE antibody testing of human placenta tissue
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IHC-P: ACE antibody testing of mouse lung tissue
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IHC-P testing of rat lung tissue
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IHC-P testing of rat lung tissue
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IHC staining of frozen human placenta with ACE antibody.
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IHC staining of frozen mouse lung with ACE antibody.
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Immunofluorescent testing of human A431 cells with ACE antibody (green) and DAPI (blue). HIER: boil tissue sections in pH6, 10mM citrate buffer, for 20 min and allow to cool before testing.
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Western blot testing of ACE antibody and recombinant human protein (0.5ng)
IHC-P: ACE antibody testing of human placenta tissue
IHC-P: ACE antibody testing of mouse lung tissue
IHC-P testing of rat lung tissue
IHC-P testing of rat lung tissue
IHC staining of frozen human placenta with ACE antibody.
IHC staining of frozen mouse lung with ACE antibody.
Immunofluorescent testing of human A431 cells with ACE antibody (green) and DAPI (blue). HIER: boil tissue sections in pH6, 10mM citrate buffer, for 20 min and allow to cool before testing.

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CodeSizePrice
NSJ-R31546-100ug100 ug£535.00
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Further Information

Application Details :
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml,Immunohistochemistry (Frozen): 0.5-1ug/ml,Immunofluorescence: 2-4ug/ml
Application Note:
The stated application concentrations are suggested starting amounts. Titration of the ACE antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Angiotensin-converting enzyme, an exopeptidase, is a circulating enzyme that participates in the body's renin-angiotensin system(RAS), which mediates extracellular volume (i.e. that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. It is secreted by pulmonary and renal endothelial cells and catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II. Using a DNA marker at the growth hormone gene locus, which they characterized as 'extremely polymorphic' and which showed no recombination with ACE, the gene was mapped to 17q22-q24, consistent with the in situ hybridization mapping to 17q23. ACE, or kininase II, is a dipeptidyl carboxypeptidase that plays an important role in blood pressure regulation and electrolyte balance by hydrolyzing angiotensin I into angiotensin II, a potent vasopressor, and aldosterone-stimulating peptide. The enzyme is also able to inactivate bradykinin, a potent vasodilator.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Gene ID #:
1636
Immunogen:
Human partial recombinant protein (AA 651-864) was used as the immunogen for this ACE antibody.
Limitation:
This ACE antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse, Rat