Caspase-2 Antibody
| Code | Size | Price |
|---|
| NSJ-R30278-100ug | 100 ug | £535.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
After reconstitution, the Caspase-2 antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.
Documents
Further Information
Application Details :
Western blot: 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting points. Titration of the Caspase-2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Caspase-2/CASP2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. Activation of Caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of Caspase-2 and sensitization to apoptosis by genotoxic stimuli. CASP2 acts both as a positive and negative cell death effector, depending upon cell lineage and stage of development.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
Amino acids 417-439 (REGYAPGTEFHRCKEMSEYCSTL) were used as the immunogen for this Caspase-2 antibody (100% homologous in human, mouse and rat). This sequence is from the small subunit.
Limitation:
This Caspase-2 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse, Rat
Uniprot #:
P42575