CDC42 Antibody

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NSJ Bioreagents
Product Code: NSJ-R30435
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-R30435-100ug100 ug£535.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
After reconstitution, the CDC42 antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.

Images

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Western blot testing of CDC42 antibody and Lane 1: ecombinant human protein 10ng; 2: 5ng; 3: 2.5ng~
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IHC-P: CDC42 antibody testing of human breast cancer tissue
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Western blot testing of CDC42 antibody and Lane 1: ecombinant human protein 10ng; 2: 5ng; 3: 2.5ng~
IHC-P: CDC42 antibody testing of human breast cancer tissue

Documents

Further Information

Application Details :
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting amounts. Titration of the CDC42 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Cell division control protein 42 homolog also known as CDC42 is a protein involved in regulation of the cell cycle. In humans, CDC42 is encoded by the CDC42 gene. CDC42 is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein(N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
An amino acid sequence from the middle region of human CDC42 (DDPSTIEKLAKNKQKPIT) was used as the immunogen for this CDC42 antibody (100% homologous in human, mouse and rat).
Limitation:
This CDC42 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Bovin, Mouse, Rat
Uniprot #:
P60953