CSB Antibody / Cockayne Syndrome B / ERCC6

Western blot: 0.5-1ug/ml

Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide

DNA excision repair protein ERCC-6 (also CS-B protein) is a protein that in humans is encoded by the ERCC6 gene. This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3' splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3, which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

Amino acids 160-205 (QAATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHLQAILGGAEVK) from the human protein were used as the immunogen for the CSB antibody.

This CSB antibody is available for research use only.

Nuclear

Antigen affinity

Human, Rat

Q03468