CSF1R Antibody / Colony Stimulating Factor 1 Receptor

Western blot: 0.5-1ug/ml

The stated application concentrations are suggested starting amounts. Titration of the CSF1R antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Colony-Stimulating Factor 1 Receptor also known as MCSFR, FMS, c-FMS, and CD115, encodes a tyrosine kinase growth factor receptor for colony-stimulating factor-1, the macrophage-and monocyte-specific growth factor. The gene is located on long arm of chromosome 5(5q32) on the Crick(minus) strand. The as-yet-unidentifiedCSF1R promoter/enhancer sequences may be confined to the nucleotides separating the 2 genes or could potentially lie within the PDGFR gene itself. The encoded protein is a single pass type I membrane protein and acts as the receptor forcolony stimulating factor 1, a cytokine which controls the production, differentiation, and function ofmacrophages. The protein is a tyrosine kinasetransmembrane receptorand member of the CSF1/PDGF receptorfamily of tyrosine-protein kinases.Kondo et al.(2000)showed that the endogenous myelomonocytic cytokine receptors for GM-CSF and macrophage colony-stimulating factor are expressed at low to moderate levels on the more primitive hematopoietic stem cells, are absent on common lymphoid progenitors, and are upregulated after myeloid lineage induction by IL-2.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

An amino acid sequence from the C-terminus of human Colony stimulating factor 1 receptor (EQGDIAQPLLQPNNYQFC) was used as the immunogen for this CSF1R antibody.

This CSF1R antibody is available for research use only.

Antigen affinity

Human, Mouse, Rat

P07333