DOG1 Antibody (TMEM16A)

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NSJ Bioreagents
Product Code: NSJ-R31414
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-R31414-100ug100 ug£535.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
After reconstitution, the DOG1 antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.

Images

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Western blot testing of DOG1 antibody and Lane 1: rat liver; 2: rat skeletal muscle lysate. Expected/observed size 114~130KD depending on glycosylation level.
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Western blot testing of DOG1 antibody and Lane 1: rat liver; 2: rat skeletal muscle lysate. Expected/observed size 114~130KD depending on glycosylation level.

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Further Information

Application Details :
Western blot: 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting amounts. Titration of the DOG1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Anoctamin-1 (ANO1), also known as oral cancer overexpressed 2 (ORAOV2), Tumor-amplified and overexpressed sequence 2 (TMEM16A), and Discovered on gastrointestinal stromal tumors protein 1 (DOG1) is a protein that in humans is encoded by the ANO1 gene. This gene belongs to a family of membrane proteins containing 8 transmembrane segments, and it is mapped to 11q13.3. ANO1 is a candidate calcium-activated chloride channel that mediates receptor-activated chloride currents in diverse physiologic processes, and it is though to be responsible for a voltage-sensitive calcium-activated chloride current. Its overexpression was reported in esophageal squamous cell carcinoma and breast cancer progression Crofelemer, an antidiarrhoeal, inhibits this channel. ANO1/DOG1 has eight transmembrane domains, its pore is large and non-selective, allowing other negatively charged species to permeate.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
An amino acid sequence from the C-terminus of human ANO1/TMEM16A/DOG1 (KVLMVELFMREEQDKQQ) was used as the immunogen for this DOG1 antibody.
Limitation:
This DOG1 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse, Rat
Uniprot #:
Q5XXA6