FER Antibody

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NSJ Bioreagents
Product Code: NSJ-R30982
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-R30982-100ug100 ug£535.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Rat
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
After reconstitution, the FER antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.

Images

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Western blot testing of FER antibody and Lane 1: HeLa; 2: rat testis; 3: rat ovary
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IHC-P: FER antibody testing of human intestinal cancer tissue
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IHC-P: FER antibody testing of rat intestine tissue
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Western blot testing of FER antibody and Lane 1: HeLa; 2: rat testis; 3: rat ovary
IHC-P: FER antibody testing of human intestinal cancer tissue
IHC-P: FER antibody testing of rat intestine tissue

Documents

Further Information

Application Details :
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting amounts. Titration of the FER antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
FPS/FES-Related tyrosine kinase, also known as TYK3, is an enzyme that in humans is encoded by the FER gene. FER protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. By in situ hybridization, Morris et al.(1990) concluded that the gene is located at 5q21-q22. Treatment of cells with JMP resulted in the release of FER from the cadherin complex and its accumulation in the integrin complex. The accumulation of FER in the integrin complex and the inhibitory effects of JMP could be reversed with a peptide that mimics the first coiled-coil domain of FER. The results suggested that the protein mediates crosstalk between CDH2 and ITGB1. In FER mutant mice, leukocyte emigration was exaggerated in response to LPS without altering vascular permeability, suggesting that the protein has a role in regulating innate immunity.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
An amino acid sequence from the middle region of human FER (FSNIPQLIDHHYTTKQ) was used as the immunogen for this FER antibody.
Limitation:
This FER antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Rat
Uniprot #:
P16591