FMO3 Antibody

Western blot: 0.5-1ug/ml

The stated application concentrations are suggested starting amounts. Titration of the FMO3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Flavin-containing Monooxygenase 3 is an enzyme that in humans is encoded by the FMO3 gene. The mammalian flavin-containing monooxygenases (FMOs) represent a multigene family whose gene products are localized in the endoplasmic reticulum of many tissues. Using quantitative RNase protection assays, FMO3 is present in low abundance in fetal liver and lung and in adult kidney and lung, and in much greater abundance in adult liver. By Western blot analysis of human liver microsomal samples ranging from 8 weeks gestation to 18 years of age, FMO1 is the major fetal isoform and FMO3 is the major adult isoform. Flavin-containing Monooxygenase 3 was expressed at intermediate levels until 11 years of age when a gender-independent increase in expression was observed during puberty. Sufferers of trimethylaminuria may display a reduced ability to metabolize substrates for FMO3 such as nicotine, amphetamine, clozapine, deprenyl, metamphetamine, tamoxifen, ethionamide, thiacetazone, and sulindac sulfide.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

An amino acid sequence from the N-terminus of human Flavin-containing Monooxygenase 3 (DDFPNFMHNSKIQEY) was used as the immunogen for this FMO3 antibody.

This FMO3 antibody is available for research use only.

Antigen affinity

Human, Mouse, Rat

P31513