HLA-DPB1 Antibody (MHC II)

Western blot: 0.5-1ug/ml

Optimal dilution of the HLA-DPB1 antibody should be determined by the researcher.

Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide

HLA class II histocompatibility antigen, DP (W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene. HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

A human HLA-DPB1 recombinant protein corresponding to amino acids R30-A258 was used as the immunogen for the HLA-DPB1 antibody.

This antibody is available for research use only.

Antigen affinity

Human, Mouse, Rat

P04440