Iduronate 2 sulfatase Antibody

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NSJ Bioreagents
Product Code: NSJ-R31017
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-R31017-100ug100 ug£535.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
After reconstitution, the Iduronate 2 sulfatase antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.

Images

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Western blot testing of Iduronate 2 sulfatase antibody and Lane 1: HeLa; 2: SMMC-7721; 3: A549; 4: MCF-7; 5: COLO cell lysate. Predicted size ~62KD~
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IHC-P: Iduronate 2 sulfatase antibody testing of human placenta tissue
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Western blot testing of Iduronate 2 sulfatase antibody and Lane 1: HeLa; 2: SMMC-7721; 3: A549; 4: MCF-7; 5: COLO cell lysate. Predicted size ~62KD~
IHC-P: Iduronate 2 sulfatase antibody testing of human placenta tissue

Documents

Further Information

Application Details :
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting amounts. Titration of the Iduronate 2 sulfatase antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Iduronate 2 sulfatase (IDS) is an enzyme associated with Hunter syndrome. IDS is involved in the lysosomal degradation of the glycosaminoglycans heparan sulfate and dermatan sulfate. Wilson et al.(1991) used an IDS cDNA clone to localize the gene to Xq28, distal to the fragile X site. Faust et al.(1992) and Daniele et al.(1993) demonstrated that the homologous Ids gene in the mouse occupies the same position on the X chromosome in relation to the FMR1, F9, and GABRA3 genes. IDS is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome. Iduronate 2 sulfatase has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6sulfatase.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
An amino acid sequence from the C-terminus of human IDS (ELCREGKNLLKHFRFRDLE) was used as the immunogen for this Iduronate 2 sulfatase antibody.
Limitation:
This Iduronate 2 sulfatase antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human
Uniprot #:
P22304