IL-2 Receptor Antibody (gamma subunit)

Western blot: 0.5-1ug/ml

The stated application concentrations are suggested starting amounts. Titration of the IL-2 Receptor gamma antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Interleukin 2 receptor gamma, also known as Common gamma chain or CD132, is a cytokine recepter subunit that is common to the receptr complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 recepter. IL2RG is a member of the type I cytokine receptor family expressed on most lymphocyte(white blood cell) populations, and its gene is found on the X-chromosome of mammals. By fluorescence in situ hybridization and PCR amplification of somatic cell hybrid DNAs, the IL2RG gene is mapped to Xq13.1. The IL2RG gene contains 8 exons and spans approximately 4.2 kb. And the gamma chain is an indispensable component of the functional IL-2 receptor. Lymphocytes expressing the common gama chain can form functional receptors for these cytokine proteins, which transmit signals from one cell to another and direct programs of cellular differentiation. The sharing of the gama subunit by several receptors explains why humans and mice that lack IL-2 entirely show milder symptoms than those with IL2RG deficiency.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

An amino acid sequence from the middle region of human IL-2 Receptor gamma subunit (HYWYKNSDNDKVQKC) was used as the immunogen for this IL-2 Receptor antibody.

This IL-2 Receptor antibody is available for research use only.

Antigen affinity

Human

P31785