Integrin linked kinase Antibody (ILK)

Western blot: 0.1-0.5ug/ml

Optimal dilution of the Integrin linked kinase antibody should be determined by the researcher.

ILK, also known as Integrin-linked kinase, is a serine-threonine protein kinase. Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK) interacts with the cytoplasmic domain of beta-1 integrin. This gene was initially described to encode a serine/ threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. Recent results showed that ILK contains 5 ankyrin-like repeats, and that the C-terminal kinase domain is actually a pseudo-kinase with adaptor function.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

Amino acids M1-H203 from the human protein were used as the immunogen for the Integrin linked kinase antibody.

This Integrin linked kinase antibody is available for research use only.

Cytoplasmic

Antigen affinity

Human, Mouse, Rat

Q13418