Lamin A/C Antibody

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NSJ Bioreagents
Product Code: NSJ-R30269
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-R30269-100ug100 ug£535.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunocytochemistry (ICC)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
After reconstitution, the Lamin A/C antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.

Images

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Western blot testing of Lamin A/C antibody and Lane 1: HeLa; 2: A431 cell lysate
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IHC-P: Lamin A/C antibody testing of human lung cancer tissue
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IHC-P: Lamin A/C antibody testing of mouse intestine tissue
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IHC-P: Lamin A/C antibody testing of rat intestine tissue
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Western blot testing of Lamin A/C antibody and Lane 1: HeLa; 2: A431 cell lysate
IHC-P: Lamin A/C antibody testing of human lung cancer tissue
IHC-P: Lamin A/C antibody testing of mouse intestine tissue
IHC-P: Lamin A/C antibody testing of rat intestine tissue

Documents

Further Information

Application Details :
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml,Immunocytochemistry: 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting points. Titration of the Lamin A/C antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Lamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size. There are three types of lamins, A, B and C. The Lamin A/C (LMNA) gene contains 12 exons. Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and C. Lamin A/C mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Protein deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
Amino acids 455-469 (RNKSNEDQSMGNWQI) were used as the immunogen for this Lamin A/C antibody (100% homologous in human, mouse and rat).
Limitation:
This Lamin A/C antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse, Rat
Uniprot #:
P02545