Menin Antibody
| Code | Size | Price |
|---|
| NSJ-R31676-100ug | 100 ug | £535.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
After reconstitution, the Menin antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.
Documents
Further Information
Application Details :
Western blot: 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting amounts. Titration of the Menin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
The MEN1 gene encodes Menin, a nuclear scaffold protein that regulates gene transcription by coordinating chromatin remodeling. It is mapped to 11q13.1. MEN1 is considered to act as a tumor suppressor gene. It has been found that that MEN1 inactivation by antisense RNA antagonizes transforming growth factor-beta-mediated cell growth inhibition. Overexpression in an inducible cell culture system downregulated the proximal promoter. In vitro studies have shown that the protein is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD. Additionally, MEN1 was essential to maintain MLL-associated myeloid transformation.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Gene ID #:
4221
Immunogen:
Human partial recombinant protein (AA 301-615) was used as the immunogen for this Menin antibody. Human MEN1 shares 93% and 94% amino acid sequence identity with mouse and rat, respectively.
Limitation:
This Menin antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse