MRP4 Antibody

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NSJ Bioreagents
Product Code: NSJ-R31565
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-R31565-100ug100 ug£535.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
The lyophilized MRP4 antibody can be stored at 40 to -200. After reconstitution, aliquot and store at -200. Avoid repeated freezing and thawing.

Images

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Western blot testing of MRP4 antibody and recombinant human protein (0.5ng)
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IHC-P: MRP4 antibody testing of human intestinal cancer tissue
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IHC-P: MRP4 antibody testing of mouse intestine tissue
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IHC-P: MRP4 antibody testing of rat intestine tissue
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Western blot testing of MRP4 antibody and recombinant human protein (0.5ng)
IHC-P: MRP4 antibody testing of human intestinal cancer tissue
IHC-P: MRP4 antibody testing of mouse intestine tissue
IHC-P: MRP4 antibody testing of rat intestine tissue

Documents

Further Information

Application Details :
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml
Application Note:
Titration of the MRP4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
ABCC4 (ATP-binding cassette, subfamily c, member 4) also known as MRP4 (Multidrug resistance associated protein 4) or MOATB, is a protein that in humans is encoded by the ABCC4 gene. It belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. This gene is mapped to chromosome 13q32. ABCC4/MRP4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of MPR4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of its activity or knockdown of the protein via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. It has been found that MRP4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Gene ID #:
10257
Immunogen:
Human partial recombinant protein (AA 1-370) was used as the immunogen for this MRP4 antibody.
Limitation:
This MRP4 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse, Rat