MyD88 Antibody

Western Blot: 0.5-1ug/ml,ELISA (Capture; mouse recombinant protein): 0.1-0.5ug/ml (BSA-free formulation available)

Optimal dilution of the MyD88 antibody should be determined by the researcher.

Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide

MYD88 (Myeloid differentiation primary response gene 88), is a protein that, in humans, is encoded by the MYD88 gene. MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL1Rs). And it is mapped on 3p22.2. MYD88 encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. Overexpression of MYD88 caused an increase in the level of transcription from the interleukin-8 promoter. The C-terminal domain of MYD88 has significant sequence similarity to the cytoplasmic domain of IL1RAP. Inhibiting the IL1R-MYD88 pathway in vivo could block the damage from acute inflammation that occurs in response to sterile cell death, and do so in a way that might not compromise tissue repair or host defense against pathogens.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

A recombinant mouse protein corresponding to amino acids S12-D263 was used as the immunogen for the MyD88 antibody.

This MyD88 antibody is available for research use only.

Antigen affinity

Mouse, Rat

P22366