MyD88 Antibody

Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml

The stated application concentrations are suggested starting points. Titration of the MyD88 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Myeloid differentiation primary response gene 88 is a protein that in humans is encoded by the MYD88 gene. MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors(IL1Rs). It a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 andToll-like receptorsignaling pathways. Qverexpression causes an increase in the level of transcription from the interleukin-8 promoter. The C-terminal domain of the protein has significant sequence similarity to the cytoplasmic domain of IL1RAP. Inhibiting the IL1R-MyD88 pathway in vivo could block the damage from acute inflammation that occurs in response to sterile cell death, and do so in a way that might not compromise tissue repair or host defense against pathogens.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

An amino acid sequence from the middle region of human MyD88 (FVQEMIRQLEQTNYR) was used as the immunogen for this MyD88 antibody.

This MyD88 antibody is available for research use only.

Antigen affinity

Human, Mouse, Rat

Q99836