OCTN2 Antibody SLC22A5

Western blot: 0.5-1ug/ml

The stated application concentrations are suggested starting amounts. Titration of the OCTN2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Solute carrier family 22 (organic cation/carnitine transporter) member 5, also called SLC22A5 or OCTN2 is a membrane transport protein associated with primary carnitine deficiency. This gene is mapped to 5q31.1. Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency(CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

An amino acid sequence from the C-terminus of mouse SLC22A5/OCTN2 (KQWQIQSQTRMQKDGEE) was used as the immunogen for this OCTN2 antibody.

This OCTN2 antibody is available for research use only.

Antigen affinity

Mouse, Rat

Q9Z0E8