Oncostatin M Antibody / OSM

Western Blot: 0.5-1ug/ml,ELISA (capture): 0.1-0.5ug/ml

Optimal dilution of the Oncostatin M antibody should be determined by the researcher.

Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide

OSM (Oncostatin M) is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is mapped on 22q12.2. It has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, a function shared by LIF, CSF3, and IL6. The direction of gene transcription was telomeric to centromeric, with the OSM gene located upstream of the LIF gene.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

A recombinant mouse protein corresponding to amino acids N25-R206 was used as the immunogen for the Oncostatin M antibody.

This Oncostatin M antibody is available for research use only.

Nuclear, cytoplasmic

Antigen affinity

Mouse, Rat

P53347