SHBG Antibody
| Code | Size | Price |
|---|
| NSJ-R31739-100ug | 100 ug | £535.00 |
Quantity:
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Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
After reconstitution, the SHBG antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.
Documents
Further Information
Application Details :
Western blot: 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting amounts. Titration of the SHBG antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Sex hormone-binding globulin (SHBG) is a glycoprotein that binds to the sex hormones androgen and estrogen. SHBG is produced mostly by the liver and is released into the bloodstream. Other sites that produce it include the brain, uterus, testes, and placenta. It has both enhancing and inhibiting hormonal influences. It decreases with high levels of insulin, growth hormone, insulin-like growth factor 1 (IGF-1), androgens, prolactin and transcortin. High estrogen, andthyroxine cause it to increase. It has been found that the monosaccharides glucose and fructose reduced human SHBG production by hepatocytes, irrespective of the presence of insulin, by downregulation of hepatocyte nuclear factor-4A and replacement of HNF4A by COUP-TFI at a cis-element within the human SHBG promoter, coincident with repression of its transcriptional activity.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Gene ID #:
6462
Immunogen:
Human partial recombinant protein (AA 30-210) was used as the immunogen for this SHBG antibody.
Limitation:
This SHBG antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human