SNRPN Antibody

Contact us
NSJ Bioreagents
Product Code: NSJ-R30868
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-R30868-100ug100 ug£535.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunocytochemistry (ICC)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
After reconstitution, the SNRPN antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.

Images

1 / 3
Western blot testing of SNRPN antibody and Lane 1: rat kidney; 2: human U87; 3: (h) HeLa; 4: (h) HMY; 5: (m) NEUR cell lysate
2 / 3
IHC-P: SNRPN antibody testing of human intestinal cancer tissue
3 / 3
ICC testing of SNRPN antibody and HeLa cells
❮❯

Western blot testing of SNRPN antibody and Lane 1: rat kidney; 2: human U87; 3: (h) HeLa; 4: (h) HMY; 5: (m) NEUR cell lysate
IHC-P: SNRPN antibody testing of human intestinal cancer tissue
ICC testing of SNRPN antibody and HeLa cells

Documents

Further Information

Application Details :
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml,Immunocytochemistry: 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting amounts. Titration of the SNRPN antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Small Nuclear Ribonucleoprotein Polypeptide N, also called SMN, is a bicistronic imprinted gene that encodes 2 polypeptides, the SmN splicing factor, which is involved in RNA processing, and the SNRPN upstream reading frame (SNURF) polypeptide. The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. SNRPN also encodes a long alternatively spliced transcript containing several small nucleolar RNAs(snoRNAs) and extends downstream to partially overlap the UBE3A gene in the antisense orientation. PWS arises from loss of function of genes in this region expressed exclusively from the paternal chromosome, suggesting that SNRPN may play a role in its etiology. The gene is mapped on 15q11.2. Analysis of maternal DNA and of SNRPN cDNA confirmed that the maternal allele is not expressed in fetal brain and heart. Deletions in the transcription unit of the imprinted gene occur in patients who have PWS or Angelman syndrome because of a parental imprint switch failure in this chromosomal domain.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
An amino acid sequence from the N-terminus of human SNRPN (FKAFDKHMNLILCDCDEF) was used as the immunogen for this SNRPN antibody (100% homologous in human, mouse and rat).
Limitation:
This SNRPN antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse, Rat
Uniprot #:
P63162