TrkC Antibody

Western blot: 0.5-1ug/ml

The stated application concentrations are suggested starting amounts. Titration of the TrkC antibody may be required due to differences in protocols and secondary/substrate sensitivity.

NTRK3(Neurotrophic Tyrosine Kinase Receptor Type 3), also known as TRKC, is a protein that in humans is encoded by the NTRK3 gene. By PCR analysis of a somatic cell hybrid panel and by fluorescence in situ hybridization with the cDNA clone, McGregor et al.(1994) mapped the NTRK3 gene to 15q24-q25. Lamballe et al.(1991) isolated and characterized TRKC, a member of the TRK family of tyrosine protein kinase genes. They found that TRKC is preferentially expressed in the brain; in situ hybridization studies showed transcripts in the hippocampus, cerebral cortex, and the granular cell layer of the cerebellum. By functional studies in HeLa cells, Muinos-Gimeno et al.(2009) demonstrated that 5 miRNAs regulate the truncated form of NTRK3. Signaling through TrkC leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. The protein is a heavily glycosylated molecule with 13 potential N-linked glycosylation sites within the extracellular domain.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

An amino acid sequence from the N-terminus of human TrkC (QLWQEQGEAKLNSQN) was used as the immunogen for this TrkC antibody.

This TrkC antibody is available for research use only.

Antigen affinity

Human, Mouse, Rat

Q16288